Autogenous adipose-derived falciform mesenchymal stem cells in the management of canine chronic hepatitis/cirrhosis: clinical audit
I’ll try to flesh out these details over the next few weeks with some more post-treatment biochem results. As yet, no post-treatment histopathology is available.
The only one of our patients who isn’t still alive at the time of writing, Jess, was euthanased on account of aggressive mammary malignancy. The possibility of stem cell potentiation of neoplasia remains a concern in human and veterinary patients. However, overall, we are feeling pretty positive about our experiences with what is otherwise a condition with a poor prognosis.
In particular it seems that portal hypertension in some of these dogs may be reversible. Inferring from resolution of ascites. This may be the first report of such a phenomenon in dogs with severe liver disease.
I’m not aware of any other published data for outcomes of stem cell treatment in canine liver disease.
We are very grateful to Biobest Laboratories; and particularly Kieran McDonald, for their enormous help with stem cell culture and general advice.
|Patient||histopathological diagnosis||clinical signs||stem cell protocol||outcome|
|7 y.o. Springer Spaniel||chronic hepatitis||recurrent icterus, malaise||40,000,000 cells into splenic vein||no further outward signs of hepatitis. Ultimately died from mammary neoplasia 2 years later.|
|5 y.o. Giant Schnauzer||Chronic hepatitis and cirrhosis||malaise, icterus, ascites, inappetence||40,000,000 cells into splenic vein||ascites managed for 3 months post-treatment with diuretics. Thereafter free from signs. Outwardly well 17 months later.|
|1 y.o, Springer spaniel||Chronic hepatitis||recurrent malaise, icterus||40,000,000 cells into splenic vein||remains alive and outwardly well 13 months post-treatment. Developed multiple acquired PSS within 2 months of stem cell treatment. Medical treatment lactulose, oral antbiotics. Intermittent mild ^ ALT. Has also received glucocorticoids intermittently both pre- and post-stem cells.|
|4 y.o. Cockerpoo||Chronic hepatitis||recurrent malaise, icterus||40,000,000 cells into splenic vein||Alive and outwardly well 8 months post-treatment. Liver enzymes within normal limits. No current medical treatment.|
|5 y.o. Cockerpoo||Chronic hepatitis||recurrent malaise, icterus, ascites, multiple acquired PSS||20,000,000 cells into splenic vein. 20,000,000 cells into liver parenchyma at multiple sites||Alive and outwardly well 3 months post-treatment. Ascites managed with tapering doses of diuretics. Has also received glucocorticoids.|