Traditionally, there has been a concern that pimobendan, a positive inotrope (inodilator), would be contraindicated in the presence of outflow tract obstruction. Obviously, left ventricular outflow tract obstruction is a big deal in cats because hypertrophic cardiomyopathy is the commonest feline heart disease and many of them exhibit dynamic or fixed obstruction. To the best … Continue reading
Do we still believe that the EPIC study was helpful? When are we using pimobendan in dogs with mitral valve disease in early 2019?
Time has moved on a bit. We’ve had the benefit of a chance to reflect on EPIC: J Vet Intern Med. 2016 Nov;30(6):1765-1779. doi: 10.1111/jvim.14586. Epub 2016 Sep 28. Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study-A Randomized Clinical Trial. Boswood A et al. https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.14586 The … Continue reading
A couple of years ago it seemed we were all more or less clear on this but, somehow, the more studies we have the muddier the waters are getting (sigh). If you want the concise version of where we are now, in my interpretation, then this is it: heart disease stage evidence-based treatment A no … Continue reading