Adipose-derived mesenchymal stem cells in the management of chronic hepatitis in Springer Spaniel
Chronic hepatitis in the English springer spaniel: clinical presentation, histological description and outcome.
Wang Y, Lian F, Li J, Fan W, Xu H, Yang X, Liang L, Chen W, Yang J.
J Transl Med. 2012 Jun 26;10:133
Adipose is a rich source of stem cells and can be harvested with minimal peri-operative morbidity. These authors compared tail vein and portal vein infusion of adipose-derived mesenchymal stem cells (ADMSCs) in rats with induced hepatopathy. At 12 weeks post treatment there were marked improvements in liver perfusion in the portal vein group despite continued administration of hepatotoxic CCl4:
Safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells for treatment of dogs with inflammatory bowel disease: Clinical and laboratory outcomes.
This week we administered 20,000,000 ADMSCs into her portal circulation via ultrasound-guided trans-splenic injection into a splenic vein.
The procedure was free from complications and we await developments…..